• News
  • Spirituality
    • Dream Interpretation
    • Angel Numbers
    • Tarot
    • Prayers
    • Spells
  • Health
  • Science
  • Celebs
  • Betting

Anxiety Disorders - The Use Of Neurosteroids As Neuromodulators


Anxiety disorders are among the most prevalent mental health diseases, causing considerable functioning deficits and frequently progressing to chronic clinical illnesses.

According to recent epidemiological research, they are the most common type of mental problem, with a high degree of comorbidity with other physical and psychiatric conditions.

DSM-IV-R currently recognizes six primary anxiety disorders: panic disorder (characterized by recurrent panic attacks), generalized anxiety disorder (characterized by frequent worrying), post-traumatic stress disorder (the result of a traumatic experience), obsessive-compulsive disorder (characterized by repetitive obsessions and the urge to perform specific acts or rituals), and specific phobia (characterized by specific stimuli eliciting fear and/or anxiety).

Anxiety disorders can be effectively treated with both medication and psychotherapy. The selective serotonin reuptake inhibitors (SSRIs) are first-line medications that show anxiolytic benefits after many weeks of treatment.

Benzodiazepines (BDZs), on the other hand, are the most frequently utilized anxiolytic drugs and have a rapid onset of action. Anxiety disorders such as panic disorder have been linked to low levels of Γ-aminobutyric acid (GABA).

COPYRIGHT_SZ: Published on https://stationzilla.com/anxiety-disorders/ by Dr. Cooney Blades on 2022-07-22T05:41:49.741Z

What Is Anxiety Disorder?

Anxiety is defined as a state of tension, disquiet, or worry that exists in the absence of an imminent threat. It is distinct from fear, which is the body's normal reaction to imminent danger.

Anxiety is a natural reaction to stress, and therefore it can be beneficial at times, making you more aware and ready to act.

Anxiety disorders and the typical emotions of anxiety are not the same thing. Many of us experience anxiety when confronted with stressful events, but if those feelings persist, the worry may become chronic. An anxiety disorder may be present when emotions of fear or uneasiness become severe, difficult to regulate, or interfere with daily life. We all experience anxiety from time to time, but with an anxiety disorder, the anxiety is rather constant and has a significant negative and invasive impact on quality of life.

What is an Anxiety Disorder?

What Are The Symptoms Of Anxiety?

Anxiety disorders have a wide range of symptoms, and no two people have the same experience. Each illness also has its own set of symptoms. The following symptoms are typical of anxiety disorders in general:

  • Being unable to be calm
  • Tingling or numbness in the hands or feet
  • Having sweaty or cold hands and/or feet
  • Irregular heartbeat
  • Feeling nauseous
  • Tightness of the muscle
  • Feeling nervous, worry, panic, fear, and unease
  • Dry mouth
  • Feeling dizzy
  • Finding it hard to sleep

Sweating, a racing heart, shortness of breath, shaking, worry, or tension are physical and psychological indications of fear and anxiety. These are cues that something could be a threat and that you need to deal with it.

Flight or fight awakens physical and psychological resources to deal with threats. Sometimes this mechanism goes into overdrive and does more harm than good, and this could suggest nervousness.

What Are Some Types Of Anxiety Disorders?

Anxiety disorders are classified into numerous kinds. Even though they all have anxiety symptoms, each has its own set of characteristics, signs, and diagnostic criteria.


Agoraphobia is the unreasonable and intense dread of being trapped in a situation from which there is no way out. People often worry about having panic attacks or other symptoms in public. This makes them avoid situations where they might feel scared, helpless, or trapped.

These avoidance habits are frequently life-threatening, prompting people to avoid driving, shopping in public, flying, and other situations. This fear can grow so intense in some circumstances that people are unable to leave their houses.

Generalized Anxiety Disorder

Generalized anxiety disorder (GAD) causes excessive worry and anxiety. This fear is hard to control and shifts regularly. People with GAD feel nervous about ordinary events, current news, relationships, or potential events.

Panic Disorder

Panic disorder causes strong, persistent panic attacks without warning. Rapid heartbeat, increased respiration, and acute fear are panic attack symptoms.

The 5 Major Anxiety Disorders

Selective Mutism

Selective mutism causes childhood worry and causes fear, embarrassment, or anxiety that keeps kids from speaking up at school or around strangers.

Selective mutism usually begins between ages 2 and 4 and is accompanied by fidgeting, lack of eye contact, and a lack of expressiveness.

Social Anxiety Disorder

Social anxiety disorder (SAD) was formerly called social phobia. This phobia may focus on specific events like public speaking or be more generic.

People with this syndrome feel constantly watched. They may be self-critical and fearful in social situations.

Shaking, rapid heartbeat, stomach distress, and fear are symptoms. These symptoms make people avoid social events.

Specific Phobias

Certain phobias involve extreme, unreasonable fear of a specific object or scenario. When people with a specific phobia face their fears, they sweat, cry, shake, have a fast heartbeat, and breathe more quickly.

People with phobias may go to tremendous measures to avoid their fear, as with other anxiety illnesses. This might generate tension and hinder everyday activities.

What Are The Effect Of Neurosteroids In The Treatment Of Anxiety?

Serotonergic System

Depression and anxiety may be caused by serotonin deficiency in several brain areas. In the 1950s, the fact that imipramine, a tricyclic compound, and iproniazid, a drug used to treat tuberculosis, helped people with depression and anxiety led to the idea that affective disorders are caused by a lack of monoamines.

Serotonin affects mood, affect, learning, aggression, and stress response. 5-HTP is a metabolite of L-tryptophan that is transformed to serotonin by aromatic L-amino acid decarboxylase. SERT also reuptakes 5-HT from cells.

SSRIs are a major advance in psychiatric medication. SSRIs limit serotonin absorption into presynaptic nerve terminals, boosting 5-HT in the synaptic cleft and extending its action at postsynaptic receptor sites. SSRIs may desensitize presynaptic 5HT1A receptors after several weeks. 5HT1A somatodendritic autoreceptor activation reduces serotonergic axon firing and boosts neurotransmission.

Serotonin transporter knockout mice and the resulting change in 5-HT homeostasis taught, for example, that 5-HT receptor density might vary. 5-HT1A and 5-HT2A receptors are decreasing, while 5-HT1C receptors are increasing. 1A, 2A, and 2C serotonin receptor subtypes are important in mood and anxiety regulation. Long-term fluoxetine alters cannabinoid type-1 receptor activation via 5HT1A receptors.

Sigma-1 Receptors

Sigma receptors are an opioid subclass. Two distinct receptors, sigma-1 and sigma-2, have been characterized.

Sigma-1 receptors are researched in learning, memory, depression, schizophrenia, and drug misuse. They can bind exogenous ligands with distinct therapeutic and pharmacological characteristics. In the conditioned fear stress model, the sigma-1 agonist (+)-SKF-10,047 reduced anxiety. Noda et al. found that neurosteroids exacerbated this effect.

Neurosteroids are likely endogenous sigma-1 ligands. Sigma ligands can counteract neurosteroids's antidepressant and anxiolytic activity. Steroids, especially progesterone, reduce sigma receptor binding in the brain and spleen. Progesterone is a very strong antagonist for the sigma-1 receptor, while pregnenolone, DHEA, and their sulfate esters are all agonists.

Pregnenolone sulfate and DHEA sulfate attenuated the conditioned fear stress response in mice in a dose-dependent manner, similar to (+)-N-allylnormetazocine (+)-SKF-10,047. NE-100, a sigma-1 antagonist, attenuated these effects. Sigma-related behavior can be regulated by endogenous neurosteroids, specifically progesterone. Sigma-1 receptor agonists' effectiveness is inversely associated with endogenous progesterone.


Anxiety is frequently treated with Γ-aminobutyric acid or serotonergic drugs. BDZs and SSRIs are common treatments because more and more evidence shows that glutamatergic neurotransmission is linked to the stress response and anxiety disorders.

Neurosteroids alter neuronal excitability by interacting with neurotransmitter receptors. While 3α, 5α-THP binds to GABAA receptors and increases Cl-channel opening time and frequency. Pregnenolone sulfate (PREGS) is a positive NMDA receptor modulator and a negative GABAA receptor modulator. Behavioral studies demonstrate that progesterone or progesterone metabolites (such as 3α, 5α-THP) boost the anxiolytic profile in anxiety tests such as the elevated plus maze or the open field test.

3α, 5α-THP administered systemically in mice demonstrated an anxiolytic character similar to benzodiazepines or barbiturates. Neurosteroids that modulate GABAA receptors are anxiolytic, sedative, and anticonvulsive. When PREGS were administered intravenously, the effects on anxiety reactions varied according to the dose and the behavior test.

A Caucasian man wearing a grey hoodie sitting with both hands placed together on his jaw while they rest on his legs
A Caucasian man wearing a grey hoodie sitting with both hands placed together on his jaw while they rest on his legs

Translocator Protein

Translocator protein (18 KDa), formerly known as the peripheral or mitochondrial benzodiazepine receptor, transports cholesterol from the outer to the inner mitochondrial membrane, restricting steroidogenesis.

Cholesterol translocation synthesizes pregnenolone and ring A-reduced neurosteroids, which may increase GABA-mediated neurotransmission. Translocator protein ligands may boost neurosteroidogenesis to treat anxiety.

Translocator protein expression on platelets or lymphocytes is reduced in anxiety disorders such as GAD, GSD, panic disorder, adult separation anxiety disorder, and PTSD.

Some translocator protein ligands exert acute anxiolytic and anti-conflict activity in animal models. Serra et al. found that selective translocator protein ligands, such as 2-phenyl-imidazo [1,2-a] pyridine derivatives (CB 34, CB 50, and CB 54), increased brain concentrations of pregnenolone, progesterone, 3α, 5α-THP, and allotetrahydrodeoxycorticosterone (3α, 5α-THDOC) and had a substantial anti-conflict effect in Vogel test. Verleye et al. discovered a favorable association between etifoxine, an anxiolytic-like chemical in rodents, and human adjustment disorder with anxiety.

In intact male rat forebrain membrane, etifoxine reduced PK11195's binding uncompetitively. Adrenalectomized-castrated (ADX-CX) rats given an anxiolytic-like dose of etifoxine had higher plasma and brain concentrations of pregnenolone, progesterone, 5α-DHP, and 3α, 5α-THP than sham-operated rats.

After activating translocator protein in the brain, increased 3α, 5α-THP synthesis may contribute to etifoxine's anxiolytic-like effects. Kita and Furukawa studied the anxiolytic-like effects of AC-5216, a translocator protein ligand, in mice, and they found that AC-5216 requires freshly produced neurosteroid hormones.

People Also Ask

What Causes An Anxiety Disorder?

An anxiety disorder may develop as a result of prolonged exposure to high levels of stress over a period of time. Someone who has a predisposition to anxiety disorders may be more likely to develop the disorder after experiencing a traumatic event. Hereditary factors have a role, as anxiety disorders frequently run in families.

What Does Anxiety Do To A Person?

Anxiety disorders are known to cause symptoms such as a racing heartbeat, palpitations, and soreness in the chest. In addition to this, there is a possibility that you will develop excessive blood pressure as well as heart disease. Anxiety disorders have been shown to increase the risk of coronary events in patients who already have heart disease.

How Do You Know You Have Anxiety Disorders?

Your worry is out of your control, and it's causing you a lot of stress. Your anxiety makes its way into all aspects of your life, including the classroom, the workplace, and your personal relationships. You are unable to let go of your worries, and you worry about a wide variety of things, including major issues like your career or health, and minor problems like doing the chores around the house.

Is Anxiety Disorder A Mental Illness?

Anxiety disorders are the most prevalent kind of mental illness, affecting roughly one in every four adults at some point in their lives. However, anxiety disorders may be treated, and there are a variety of treatments that are proven to be helpful. Most people get better after treatment, which allows them to live normal, useful lives.


Neurosteroids are potent central nervous system modulators that alter a variety of neurophysiological processes. They begin to act at low doses and may affect various neurotransmitter pathways.

Their capacity to control several pathways that interact with one another makes them promising candidates for the pharmacotherapy of anxiety disorders, especially when combined with other mental illnesses such as mood disorders.

One goal could be to find a synthetic NS with strong anxiolytic-like effects that can be easily distinguished from sedative/ataxic effects.

The new medications should have a high oral bioavailability. NS appears to be less addictive than benzodiazepines.

Reduced abuse liability, combined with a lack of interaction with ethanol, may provide an advantage over currently available benzodiazepine anxiolytics.

Furthermore, translocator protein ligands can increase steroid synthesis, restore neurosteroid-mediated neurotransmission in the brain, and so compensate for anxiety conditions.

People with anxiety disorders have been found to have lower levels of translocator protein. Using ligands to increase translocator protein steroidogenesis may be a new way to treat anxiety.

Share: Twitter | Facebook | Linkedin

About The Authors

Dr. Cooney Blades

Dr. Cooney Blades

Recent Articles

  • Nidhi Shah An Indian Television Actress


    Nidhi Shah An Indian Television Actress

    Nidhi Shan is a renowned model and actress in her own country of India. The television show "Tu Ashiqui" made the actor popular for her performance as Poorva Sharma in the show. Mere Dad Ki Maruti was the film in which she made her first appearance.

  • Khushali Kumar - An Indian Actress And Fashion Designer


    Khushali Kumar - An Indian Actress And Fashion Designer

    Khushali Kumar is a well-known fashion designer, dancer, and actress from India. She is most known for being the daughter of Gulshan Kumar Dua, the famous vocalist and founder of the group T. Series. She is also well known for her acting profession, which has seen her appear in several films and television programs throughout her cinematic career.

  • Krish Chauhan - An Indian Actor And Dancer Who Started Acting As A Child Artist


    Krish Chauhan - An Indian Actor And Dancer Who Started Acting As A Child Artist

    Krish Chauhan is a rising star in the entertainment industry, working as an actor, dancer, and television personality. He is most known for his outstanding performances in several television series and films, including Bin Kuch Kahe (2017), BackBencher (2021), and Devi Adi Parashakti (2020).

  • Aashay Mishra - An Indian Television Actor And Model


    Aashay Mishra - An Indian Television Actor And Model

    Aashay Mishra is an Indian television actor who mostly works in Hindi television serials and Bollywood films. He has also appeared in several international films. In the television show Pyaar Ke Papad, he played the part of Omkar Gupta, which brought him a great deal of recognition and popularity.

  • Dream About Being Held Hostage - A Symbol Of Your Lack Of Character

    Dream Interpretation

    Dream About Being Held Hostage - A Symbol Of Your Lack Of Character

    We'll talk about dream about being held hostage in this post, potential scenarios, and their symbolic interpretations. It will perhaps help you understand how your dream links to reality. Though it's not a frequent dream motif, being taken captive can happen in dreams. Being a hostage in your dream might symbolize a number of different things in your waking life.

  • Dream Of Being In Grocery Store - Symbolizes Your Desire To Improve Your Skills

    Dream Interpretation

    Dream Of Being In Grocery Store - Symbolizes Your Desire To Improve Your Skills

    Have you ever dream of being in grocery store? You need to feel alive emotionally or physically as represented in your dream by the act of buying food or shopping within grocery stores or supermarkets. Unlike when you dream about other shopping dreams, the groceries you are buying are necessities to sustain life.

  • Dream About Ex Boyfriend And His Family Meaning

    Dream Interpretation

    Dream About Ex Boyfriend And His Family Meaning

    Having a dream about ex boyfriend and his family represents spiritual and emotional development. Your perception of yourself is skewed. You are dealing with a difficult situation that requires mental effort. Your love life is making you unhappy, according to the dream. You must adopt an attribute that one of your friends has.

  • Dream Of Being In Labor - New Area Of Your Personality

    Dream Interpretation

    Dream Of Being In Labor - New Area Of Your Personality

    The dream of being in labor, giving birth, or being pregnant might be dreadful, but they can also include a sigh of relief at the conclusion. We'll need to go into the depths of your subconscious and consider what's going on in your day-to-day life to interpret your dream about becoming pregnant.

  • Spiritual Meaning Of Receiving Money In A Dream

    Dream Interpretation

    Spiritual Meaning Of Receiving Money In A Dream

    Spiritual meaning of receiving money in a dream could be a sign of financial difficulties, a spiritual attack, or temptation. This could also be a sign of wealth, freedom, fulfillment, love, heavenly knowledge, success, unanticipated fortune, and prosperity, according to certain Christian dream interpreters.

  • Having A Dream Within A Dream Spiritual Meaning

  • Dreams About Gasping For Air - What Does It Mean?

  • Memphis Police Disband Unit After The Death Of Tyre Nichols

  • 666 Angel Number - A Sign Of Balance

  • Out Of Love Cast - Overview Of Characters Of The Amazon Prime Series