Natural Sources, Benefits And Side Effect Of Dl-phenylalanine Before Bed
Taking DL-phenylalanine before bed is a topic of interest for some individuals seeking potential sleep-related benefits. DL-phenylalanine is an amino acid that plays a role in neurotransmitter production, including dopamine and norepinephrine.
Author:Suleman ShahReviewer:Han JuDec 25, 20231.9K Shares52K Views
Sleep is an essential component of a healthy lifestyle, as it plays a vital role in our physical and mental well-being. Yet, many people struggle with sleep disordersand insomniaor simply have difficulty winding down at night. While there are various remedies and strategies to improve sleep, some individuals have turned to supplements like DL-Phenylalanine to aid their sleep quality and overall well-being.
Dl-phenylalanine, often abbreviated as DLPA, is an amino acid that is essential for the synthesis of various neurotransmitters in the brain. It is a combination of two forms of phenylalanine: L-phenylalanine and D-phenylalanine. L-phenylalanine is an essential amino acid, which means the body cannot produce it and must obtain it from dietary sources.
On the other hand, D-phenylalanine does not naturally occur and is typically synthesized in the laboratory. In this comprehensive guide, we'll explore the potential benefits of taking DL-Phenylalanine before bed, its mechanisms, safety considerations, and other factors to help you make an informed decision.
What Is Dl-Phenylalanine?
Phenylalanine is an amino acid. Phenylalanine comes in three different forms: L-, D-, and DL-. Foods like beef and eggs naturally contain L-phenylalanine. The building components of protein are amino acids. One necessary amino acid is L-phenylalanine.
It is the sole phenylalanine form that may be found in proteins. It is currently unknown what function d-phenylalanine serves in the body; it is not a necessary amino acid. In a lab, DL-phenylalanine is produced.
Phenylalanine is used to treat vitiligo, a condition that results in the development of white spots on the skin. In addition, it is claimed to treat depression, aging skin, chronic pain, attention deficit hyperactivity disorder (ADHD), and many other conditions, albeit the majority of these applications lack scientific backing.
Dl-Phenylalanine Benefits
Phenylalanine is an amino acid that serves as a fundamental building block for the various proteins produced in the body. This amino acid is essential for a wide range of biological processes and is involved in the synthesis of several important neurotransmitters.
There are three forms of phenylalanine: D-phenylalanine, L-phenylalanine, and DL-phenylalanine. DL-phenylalanine, the focus of this article, is a unique combination of L-phenylalanine and its synthetic mirror image, D-phenylalanine.
Depression
Limited clinical research conducted in the 1980s suggests that L-phenylalanine or DL-phenylalanine might be helpful in the treatment of depression. These studies hinted at the potential of phenylalanine to influence neurotransmitter balance, specifically by enhancing the production of mood-regulating chemicals in the brain.
However, it's important to note that this research remains inconclusive, and further studies are needed to verify these claims.
Pain Management
Some older studies have explored the potential of D-phenylalanine for relieving pain. The mechanisms behind this effect are not entirely clear, but it may involve interactions with the body's natural pain-relief mechanisms. Research in this area has yielded mixed results, indicating that phenylalanine may not be universally effective for pain relief.
Vitiligo
Vitiligo is a skin condition characterized by the loss of pigment in some regions of the skin. Interestingly, taking L-phenylalanine orally or applying it to the skin, often in combination with UVA light therapy, appears to improve the symptoms of vitiligo. This suggests that phenylalanine may play a role in pigmentation and skin health.
Alcohol Withdrawal
A 2011 study suggested that a supplement containing D-phenylalanine, along with other amino acids, could help alleviate the symptoms of alcohol withdrawal. Alcohol withdrawal can be a challenging and uncomfortable process, and while phenylalanine may have potential benefits, more research is necessary in this specific context.
Joint Function
D-phenylalanine may hold promise in supporting healthy joint function, particularly in older individuals. The exact mechanisms behind this effect are not fully understood, but it may be related to the amino acid's influence on pain perception and inflammatory processes.
However, it's important to emphasize that there is limited scientific evidence to support the use of phenylalanine for most other purposes, such as attention-deficit hyperactivity disorder (ADHD), chronic pain, and anti-aging skincare. While some individuals may report positive outcomes, more rigorous research is needed to substantiate these claims.
Side Effects Of Dl-Phenylalanine Before Bed
Dl-phenylalanine before bed offers potential benefits, but it's essential to be aware of the possible side effects associated with its use. These side effects can vary in intensity and may be more pronounced in some individuals than in others. Here are some of the potential side effects of taking DL-Phenylalanine:
Anxiety
Some individuals may experience increased feelings of anxietywhen taking DL-Phenylalanine. This may be related to its impact on neurotransmitter levels in the brain.
Headache
Headaches are a relatively common side effect of DL-Phenylalanine supplementation. If you experience persistent or severe headaches, it's advisable to discontinue use and consult a healthcare professional.
Constipation
Nausea
Nausea is another possible side effect. It can range from mild queasiness to more severe nausea in some cases.
Heartburn
Individuals taking DL-Phenylalanine may experience heartburn or acid reflux, which can be uncomfortable.
Fatigue
Paradoxically, DL-Phenylalanine may cause fatigue in some individuals despite its potential for enhancing mood and alertness. Fatigue is often considered an adverse reaction.
Jitteriness
DL-Phenylalanine may cause jitteriness or restlessness in some users, which can be unsettling.
Hyperactivity In Children
In some cases, DL-Phenylalanine has been associated with increased hyperactivity in children. It's essential to exercise caution when considering this supplement for pediatric use.
It's crucial to adhere to recommended dosages and closely monitor your response to DL-Phenylalanine. Doses exceeding 5,000 mg per day are not advisable, as they can be toxic and may lead to nerve damage. The safety and efficacy of high doses have yet to be well-established.
DL-Phenylalanine should not be used in combination with antipsychotic drugs, as it may cause or exacerbate symptoms of tardive dyskinesia (TD). TD is characterized by involuntary movements of the tongue, lips, face, trunk, and limbs and can occur in individuals taking antipsychotic medications over an extended period.
People with the genetic disorder phenylketonuria (PKU) should exercise extreme caution when considering DL-Phenylalanine or any supplement containing phenylalanine. High levels of phenylalanine in the blood can lead to severe brain damage, delayed growth, intellectual disability, and disruptions in the transport of other amino acids to the brain. Individuals with PKU should carefully monitor their phenylalanine intake and consult a healthcare provider for guidance.
If you experience any adverse side effects after taking a phenylalanine supplement or consuming high-protein foods rich in phenylalanine, it is crucial to contact your healthcare provider promptly. They can provide tailored advice and recommendations based on your specific situation, ensuring your well-being and safety while using DL-Phenylalanine or any dietary supplement.
Why Do People Take Phenylalanine?
Even though phenylalanine is an amino acid that can be used for many things, it's not generally seen as a standard way to treat a number of health problems. Still, over the years, phenylalanine has been studied as a possible treatment for a number of health problems, such as chronic pain, sadness, ADHD (Attention-Deficit/Hyperactivity Disorder), and vitiligo, a skin disease that causes patches of light skin.
Chronic Pain
Some people are interested in how phenylalanine might help with chronic pain. Some studies, primarily done in the 1970s and 1980s, showed that D-phenylalanine might help ease pain. But these results have been met with mixed reactions, and there are better ways to treat pain than phenylalanine.
Depression
Some studies from the past have shown that phenylalanine may not be very effective at treating sadness. Neurotransmitter levels may be affected by phenylalanine, which could help keep moods stable. Still, the research in this area isn't clear, and more in-depth studies are needed to prove that it works as a depression treatment.
Adhd
There isn't a lot of research on or agreement among doctors about how to use phenylalanine to treat ADHD. Even though amino acids help neurotransmitters work, more research needs to be done on how phenylalanine affects ADHD symptoms.
Vitiligo
Some research studies have shown that people with vitiligo may benefit from taking L-phenylalanine along with ultraviolet A (UVA) light treatment. This points to a possible role in skin health and color. But more study is needed to find out if it works for this reason.
One problem with working with phenylalanine is that there are no set amounts that are best for each situation. Also, the quality and active ingredients in supplements can be very different from one maker to the next, which makes it hard to set an average amount. Therefore, phenylalanine's use in medicine is still new and isn't usually suggested or suggested as the primary treatment for most of the conditions listed.
Even though phenylalanine is an interesting amino acid that might be good for your health in some situations, it is not usually the first choice for those conditions. Because there is a limited amount of research on phenylalanine and the studies that are there are only sometimes consistent, people should be careful and look into it more before considering it as a possible treatment for specific health problems. People should talk to medical professionals about more established and scientifically proven methods for their specific health problems.
L-Phenylalanine Benefits
L-phenylalanine can make the neurotransmitters dopamine, norepinephrine, and epinephrine more of. It can help a thyroid that isn't working well make more T4 and T3. L-phenylalanine can help you think more clearly, especially when you're under a lot of stress. It helps you make better choices, be more creative, be more cognitively flexible, and remember things better.
L-phenylalanine changes into L-Tyrosine, which then changes into L-DOPA, which is what makes dopamine. Your body also makes melanin with L-DOPA. This process of change helps get rid of harmful quinones. It gets rid of heavy metals like lead and mercury that can build up in nerves and hurt them.
Your brain can make norepinephrine (noradrenaline) from the dopamine it doesn't use. Norepinephrine is essential for learning, sleeping, feeling good, paying attention, and resting.
When taken with ADHD or ADD drugs like Ritalin or Adderall, L-Phenylalanine may work well as a nootropic. It helps your brain get more plasma dopamine, which makes drugs that are used to increase dopamine uptake work better.
Can Dl-Phenylalanine Interact With Other Medications
DL-Phenylalanine may interact with certain medications, and it is essential to talk to a healthcare provider before taking DL-Phenylalanine if you are currently being treated with any of the following medications.
Monoamine Oxidase Inhibitors (MAOIS)
Phenylalanine supplementation may cause a severe increase in blood pressure in people taking these drugs. This severe increase in blood pressure (also called "hypertensive crisis") can lead to a heart attack or stroke. Individuals taking MAOIs should avoid foods and supplements containing phenylalanine.
Baclofen
The absorption of baclofen, a medication used to relieve muscle spasms, may be reduced by phenylalanine. Therefore, it is best to avoid taking this medication with a meal, especially one that is high in protein content, or with phenylalanine supplements.
Levodopa
A few case reports suggest that phenylalanine may reduce the effectiveness of levodopa, a medication used to treat Parkinson's disease. Some researchers speculate that phenylalanine may interfere with the absorption of this medication. Therefore, phenylalanine should not be taken at the same time as levodopa.
Selegiline
L-phenylalanine and the selective MAO inhibitor selegiline may increase the levels of dopamine, norepinephrine, and epinephrine in the brain, which can lead to side effects such as headache, nausea, and insomnia.
What Are The Natural Sources Of L-Phenylalanine?
L-phenylalanine is an essential amino acid, which means that the human body cannot produce it on its own and must obtain it from dietary sources. Fortunately, it can be found in various natural food items, making it accessible to those who maintain a well-balanced diet.
Protein-Rich Foods
A primary source of L-Phenylalanine is protein-rich foods. Meats, such as beef, poultry, and pork, contain significant amounts of L-Phenylalanine. Lean cuts of these meats are often preferred for their lower fat content and high protein levels, making them a nutritious source of this essential amino acid.
Dairy Products
Dairy items like milk, cheese, and yogurt also provide L-Phenylalanine. These foods are not only a source of amino acids but also offer essential nutrients like calcium and vitamin D, contributing to overall health.
Fish And Seafood
Various fish and seafood options, including salmon, cod, and shrimp, are rich in L-Phenylalanine. These sources are not only protein-packed but also provide omega-3 fatty acids, known for their numerous health benefits.
Eggs
Eggs are another natural source of L-phenylalanine. Both the egg white (albumen) and the yolk contain this amino acid, making eggs a versatile and readily available protein source.
Legumes
Plant-based sources of L-Phenylalanine include legumes like beans, lentils, and peas. These foods are not only rich in essential amino acids but also provide dietary fiber and essential vitamins.
Nuts And Seeds
Nuts and seeds, such as almonds, sunflower seeds, and peanuts, are natural sources of L-Phenylalanine. They are often considered healthy snacks and can be incorporated into various dishes and dietary plans.
Soy Products
Soy-based foods like tofu, tempeh, and soybeans are vegetarian and vegan-friendly sources of L-Phenylalanine. They provide a complete source of protein and can be essential components of plant-based diets.
Incorporating a variety of these natural food sources into your diet can help ensure an adequate intake of L-Phenylalanine, supporting overall health and well-being.
Dl-phenylalanine Before Bed - FAQs
Can You Take Phenylalanine At Night?
These chemicals usually make you feel more alert, and their amounts are highest in the morning and lowest at night. If you take phenylalanine late in the day, it might raise catecholamines when they should be going down to get ready for sleep.
When Is The Best Time To Take Dl-Phenylalanine?
It is best to take phenylalanine between meals because the protein in food may fight with phenylalanine for entry into the brain, making it less effective.
Is Dl-Phenylalanine Safe To Take?
DL-phenylalanine might be safe when used as medicine for a short time. Anxiety, headaches, and constipation are some of the side effects that could happen.
Does Dl-Phenylalanine Increase Dopamine?
Dopamine, norepinephrine, and epinephrine are all made from phenylalanine. Taking extra DL-phenylalanine has been shown to increase the amount and activity of dopamine.
Conclusion
DL-Phenylalanine, or DLPA, holds the potential to influence various aspects of health, particularly sleep quality when taken before bed. This amino acid's intriguing combination of L-phenylalanine and D-phenylalanine has been associated with benefits such as improved mood, pain relief, and potential support for skin conditions like vitiligo.
It is essential to approach DL-Phenylalanine before bed with caution, given the limited scientific evidence and the possibility of side effects like anxiety and headaches. Additionally, interactions with certain medications, particularly monoamine oxidase inhibitors (MAOIs), should be carefully considered to avoid potentially dangerous consequences.
As the role of DL-Phenylalanine in health and wellness continues to be a subject of research and exploration, individuals seeking to integrate it into their bedtime routine should consult with healthcare professionals. In doing so, they can make informed decisions tailored to their specific needs, recognizing that DL-Phenylalanine, while promising, is not a universally recognized or first-line solution for sleep or other health concerns.
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Suleman Shah
Author
Suleman Shah is a researcher and freelance writer. As a researcher, he has worked with MNS University of Agriculture, Multan (Pakistan) and Texas A & M University (USA). He regularly writes science articles and blogs for science news website immersse.com and open access publishers OA Publishing London and Scientific Times. He loves to keep himself updated on scientific developments and convert these developments into everyday language to update the readers about the developments in the scientific era. His primary research focus is Plant sciences, and he contributed to this field by publishing his research in scientific journals and presenting his work at many Conferences.
Shah graduated from the University of Agriculture Faisalabad (Pakistan) and started his professional carrier with Jaffer Agro Services and later with the Agriculture Department of the Government of Pakistan. His research interest compelled and attracted him to proceed with his carrier in Plant sciences research. So, he started his Ph.D. in Soil Science at MNS University of Agriculture Multan (Pakistan). Later, he started working as a visiting scholar with Texas A&M University (USA).
Shah’s experience with big Open Excess publishers like Springers, Frontiers, MDPI, etc., testified to his belief in Open Access as a barrier-removing mechanism between researchers and the readers of their research. Shah believes that Open Access is revolutionizing the publication process and benefitting research in all fields.
Han Ju
Reviewer
Hello! I'm Han Ju, the heart behind World Wide Journals. My life is a unique tapestry woven from the threads of news, spirituality, and science, enriched by melodies from my guitar. Raised amidst tales of the ancient and the arcane, I developed a keen eye for the stories that truly matter. Through my work, I seek to bridge the seen with the unseen, marrying the rigor of science with the depth of spirituality.
Each article at World Wide Journals is a piece of this ongoing quest, blending analysis with personal reflection. Whether exploring quantum frontiers or strumming chords under the stars, my aim is to inspire and provoke thought, inviting you into a world where every discovery is a note in the grand symphony of existence.
Welcome aboard this journey of insight and exploration, where curiosity leads and music guides.
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