Inflammatory bowel disorders are defined based on their principal symptoms, which are typically diarrhea, constipation, or alternating symptoms of both, and are exacerbated by stress. These disorders include ulcerative colitis, which can also affect other regions of the body, and Crohn's disease, among others. The GI tract epithelium is integrated with the enteric nervous system, a network of neurons that regulate gut function and where both CB1 and CB2 receptors are abundant, making treatment of IBS and IBD with CBD easier.