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3D Living Cell Simulation - Researchers Developed Them


Living Cell Simulation- It is estimated that every live cell includes a busy microcosm with thousands of components responsible for various functions such as energy synthesis, protein manufacturing, gene transcription, and others. Creating a complete living cell simulationof lifeincludes establishing a complete quantum mechanical simulation of everything in a cell, down to the level of every solitary electron. It was developed by scientists at the University of Illinois Urbana-Champaign, who created a three-dimensional simulation that replicated these physical and chemical features at the particle level, thereby establishing a dynamic model that replicated the behavior of a natural cell.

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What Is Cell Simulation?

Cell simulation is a way of structuring simulation models to increase the efficiency of experimental results. There are several advantages to using this method, including the fact that it can reconcile the event-based approach to simulation modelling with the activity-based approach and has implications for modelling massive systems.

Can We Simulate A Cell?

Students may learn about biology while also practising their data analysis abilities through living cell simulations. While simulations cannot wholly replace real-world experiences, they are essential in scientific research and educational settings. Even if a workable computer model of live cells were a little shaky and inaccurate, it would be an extremely important tool for researchers. Research biologists might experiment with different concepts for studies before dedicating the necessary time and resources to carry them out in the laboratory. For example, drug makers may speed up their hunt for novel antibiotics by focusing their attention on molecules whose inhibition would cause the most disruption in a bacteria. Bioengineers such as myself could transplant and rewire the genes of virtual microorganisms to design modified strains with specific characteristics—the ability to fluoresce when infected by a particular virus, for example, or the ability to extract hydrogen gas from petroleum—without the risks associated with altering real microorganisms. Assuming we can learn to create models that are sophisticated enough to simulate human cells in the future, these tools could revolutionize medical research by allowing researchers to carry out experiments that would otherwise be impossible because many types of human cells cannot be cultured at the present time.

Living Cell Simulation Through NVIDIA GPUs

Scientists from the University of Illinois at Urbana-Champaign created a 3D simulation that duplicates these physical and chemical properties at the particle level, resulting in an entirely dynamic model that resembles the behavior of a natural cell.

The experiment, published in the journal Cell, simulates a live minimum cell, which comprises a reduced set of genes required for survival, function, and reproduction. According to the researchers, the model uses NVIDIA GPUs to replicate 7,000 genetic information processes across 20 minutes of the cell cycle, making it the most prolonged and most complicated cell simulation to date. Because minimal cells are more superficial than naturally occurring cells, they are easier to replicate digitally. "Even a simple cell requires 2 billion atoms," said Zaida Luthey-Schulten, a chemistry professor and co-director of the University of California, Berkeley's Center for the Physics of Living Cells. "Without GPUs, you can't produce a 3D model like this in a realistic human time scale." Once tested and developed, it can assist scientists in predicting how changes to the environment or genomes of real-world cells would alter their function.

However, modest cell modelling can provide scientists insight into the physical and chemical processes that underpin actual cells even at this early level. "What we discovered is that basic behaviors arise from the simulated cell — not because we coded them in, but because the kinetic parameters and lipid processes in our model were right," she explained.

Modeling With Mycoplasma

The Illinois researchers created the live-cell model by simulating one of the most superficial living cells, a parasite microbe called mycoplasma. The model was based on a trimmed-down version of a mycoplasma cell created by scientists at the J. Craig Venter Institute in La Jolla, California, which contained just under 500 genes to keep it alive. A single E. coli cell, by comparison, has around 5,000 genes. A human cell has around 20,000.Luthy-team Schulten's then used available features of the mycoplasma's inner workings, such as amino acids, nucleotides, lipids, and small molecule metabolites, to construct the model, which included DNA, RNA, proteins, and membranes. "We have enough reactions that we could replicate everything known," she explained.

The researchers used Lattice Microbes software on NVIDIA Tensor Core GPUs to run a 20-minute 3D simulation of the cell's life cycle before it begins to enlarge or repeat its DNA significantly. According to the model, the cell spent most of its energy transferring chemicals across the cell membrane, which matches its profile as a parasitic cell.

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About The Authors

Suleman Shah

Suleman Shah- Suleman Shah is a researcher and freelance writer. As a researcher, he has worked with MNS University of Agriculture, Multan (Pakistan) and Texas A & M University (USA). He regularly writes science articles and blogs for science news website immersse.com and open access publishers OA Publishing London and Scientific Times. He loves to keep himself updated on scientific developments and convert these developments into everyday language to update the readers about the developments in the scientific era. His primary research focus is Plant sciences, and he contributed to this field by publishing his research in scientific journals and presenting his work at many Conferences. Shah graduated from the University of Agriculture Faisalabad (Pakistan) and started his professional carrier with Jaffer Agro Services and later with the Agriculture Department of the Government of Pakistan. His research interest compelled and attracted him to proceed with his carrier in Plant sciences research. So, he started his Ph.D. in Soil Science at MNS University of Agriculture Multan (Pakistan). Later, he started working as a visiting scholar with Texas A&M University (USA). Shah’s experience with big Open Excess publishers like Springers, Frontiers, MDPI, etc., testified to his belief in Open Access as a barrier-removing mechanism between researchers and the readers of their research. Shah believes that Open Access is revolutionizing the publication process and benefitting research in all fields.

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