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How Can PEA For Migraines Alleviate Symptoms?

Pea for migraines, the revolutionary remedy that has garnered widespread attention in the realm of headache relief, offers a unique and natural approach to alleviating the persistent discomfort associated with migraines.

Alexander McCaslin
Jan 19, 2024404 Shares26942 Views
Migraines afflict millions of people worldwide, causing excruciating pain and disrupting daily life. While conventional treatments exist, an increasing number of migraine sufferers are exploring natural alternatives like Palmitoylethanolamide (PEA) for relief. In this comprehensive guide, we delve into the potential benefits, mechanisms, and scientific evidence surrounding PEA for migrainesand management options.

What Is A Migraine?

Woman Having Migraine
Woman Having Migraine
Migraines induce acute throbbing or pulsating pain on one side of the brain. Nausea, vomiting, and light and sound sensitivity are common. Migraine discomfort may last hours to days and disrupt everyday life.
Auras may precede or accompany headaches in certain persons. Flashes of light or blind spots may be signs of an aura, as can tingling on one side of the face or in an arm or leg and trouble speaking. Migraines may be prevented and reduced with medication. The correct medications, self-help, and lifestyle adjustments may assist.

What Are The Symptoms Of Migraines?

A headache is the main sign of a migraine. A hammering or throbbing sensation is one way to describe pain. It may start as a subtle aching and progress to mild, moderate, or severe pulsating pain.
Your headache will progress from mild to severe if you do nothing. If you're experiencing chronic headaches, the pain may move from side to side, impact only the front or back of your head, or even permeate the whole structure. Pain may radiate from the temples or around the eyes; it may also affect the jaw, sinuses, cheek, or neck. Migraine headaches might often cause other symptoms, too.
  • Occupation is limited by light, sound, and smell.
  • Experiencing queasy tummy, vertigo, nausea, and abdominal discomfort.
  • A lack of hunger levels.
  • Being very hot (sweating) or chilly (chills).
  • Skin tone is pale.
  • Feeling exhausted.
  • Feeling lightheaded and in a visual haze.
  • Sore head of hair.
  • A rare case of diarrhea.
  • Indigestion (infrequent).
  • A severe migraine might linger for days, although the average migraine only lasts about four hours.

Prodrome Symptoms

  • Concentration issues.
  • Anxietyand sadness.
  • Struggling with reading and speaking.
  • Trouble getting to sleep. Wide open.
  • Feeling queasy.
  • Feeling exhausted.
  • Photosensitivity and acoustic sensitivity.
  • Appetite pangs.
  • Enhanced need to urinate.
  • Rigidity of the muscles.

Aura Symptoms

  • Paresthesia, tingling, and loss of sensation.
  • Problems with vision. You may experience kaleidoscopic vision, areas of blurriness, sparkles, or lines in your field of vision.
  • Partial blindness occurs suddenly.
  • A need for strength in a particular area.
  • Speech changes.

Headache Symptoms

  • There is discomfort and stiffness in the neck.
  • Sadness, trepidation, and worry.
  • Intolerance to sound, scent, and light.
  • Congestion in the nose.
  • No sleep.
  • Appetite loss and indigestion.

Postdrome Symptoms

  • Absence of focus.
  • Low spirits.
  • Feeling exhausted.
  • I need help understanding.
  • Feeling elated.
A Woman Touching her Head
A Woman Touching her Head

Causes Of Migraines

If you suffer from migraines, here are ten things you can do to prevent them:


Muscle strain, gastrointestinal issues, and an increased risk of heart attack are just a few of the many ailments that stress may induce. Regrettably, migraines may also be brought on by stress.
Feeling stressed out could be a result of having an extremely full schedule, an endless list of things to do, or frequent meetings. Overexertion during an incredibly strenuous exercise is one example of the kind of physical stress that may trigger migraines.


Anxiety, which is comparable to stress, maybe the underlying cause of migraines. There is a continuum from episodic anxiety (caused by specific situations) to chronic anxiety (a disease characterized by persistent and progressive worsening of symptoms). There is a vicious cycle that may start when migraines bring on anxiety.
Frustration and anxiety might set in when you realize you can do little to prevent attacks and are constantly fretting about when the next one will strike. Anxiety, in turn, may bring on a migraine.


Hormones probably play a role in why women get chronic migraines at a higher rate than males (15 days a month or more). Period migraines affect up to 19% of women, which may start anywhere from two days before to three days after a woman's period begins, and 60% of those women also get headaches at other times of the month.
Hormone replacement treatment, menopause, some types of birth control, pregnancy, and lactation may all contribute to migraines.

Not Enough (or Too Much) Sleep

One of the most critical components of good healthis enough sleep, and migraines may result from insufficient sleep.
An attack might be triggered by an imbalance in the amount of sleep, an irregular sleep schedule, or both. Also, teeth grinding while sleeping and sleep apnea, in which the airway gets continually closed while you sleep, may lead to migraine headaches.

Caffeine (or Caffeine Withdrawal)

Although caffeine may sometimes alleviate headaches, it may be the cause of migraines for those who are caffeine addicts. It is unclear why coffeecauses migraines, but one possible explanation is that it alters the levels of adenosine, a naturally occurring neurotransmitter that also rises during a migraine.
Caffeine addiction may develop in those who use it three times or more each week. Migraine patients may find that they have attacked more often when they do not consume the usual amount of coffee.


The health risks associated with smoking include an increased likelihood of cardiovascular disease, cerebrovascular accident, and lung cancer, among many others. Add headaches to that list as well. Less blood reaches the brain when your blood arteries constrict due to the nicotine in cigarettes.
It may cause migraine headaches. Migraines may also be caused by nicotine withdrawal, especially for those who smoke less often. Take smoking as an example. If you start in the morning and wait until afternoon to light up again, you run the risk of experiencing a migraine during that time. In the long run, nicotine withdrawal headaches are preventable if you stop smoking completely.


Certain drugs may cause migraines. But these same drugs can be vital for other aspects of your health as well. Never discontinue taking a drug without first consulting your doctor.
Prescribed or over-the-counter migraine treatment has the potential to exacerbate migraine symptoms in rare cases. When migraines become more frequent, people often use more medicine to alleviate their pain, which may lead to an overuse headache, known as medication overuse.

The Weather

A migraine might be on the horizon when a storm is on the horizon. For others, migraines are brought on by abrupt shifts in the weather. Like an impending storm, it's just one weather pattern for some people. A shift in temperature, for example, can mean something entirely different to other people.
When many elements are influencing the weather, migraines are more likely to occur. For instance, a sudden shift in the weather might push you over the line into migraine zone if you're already struggling to get enough sleep.

Certain Lights, Noises, And Smells

Overactive senses could cause your migraines. Migraine sufferers may find that specific environments, such as those with loud music, very bright lighting, or strong odors (such as paint or perfume), bring on an attack.
People who suffer from migraines react differently to certain sounds, odors, and lighting. An example of this would be how a particular scent might set off an allergic reaction in one individual while causing no such reaction in another.

Specific Foods And Drinks

Certain foods or drinks may bring on migraines in specific individuals, particularly when combined with other triggers. Migraine triggers include the following everyday meals and beverages:
  • Alcohol.
  • Decadent chocolate.
  • The foods that are fermented or pickled.
  • Meats that have been cured or processed.
  • Moldered cheeses.
  • A yeast.
  • Missonibazole dibasic (MSG).
Upset Male With Headache
Upset Male With Headache

What Is Palmitoylethanolamide (PEA)?

Fatty acid palmitoylethanolamide occurs naturally in all parts of the body. Potentially involved in the Endocannabinoid System (ECS) and other biological pathways.
Under both mental and physical stress, the body increases its production of PEA. It may also be produced in response to infections, pain, poisons, ultraviolet light damage, pesticides, gluten, and carcinogens. Among the many potential medical uses for palmitoylethanolamide are its anti-inflammatory and analgesic effects.
One compound that shows promise in the treatment of neurological illnesses is palmitoylethanolamide, which possesses nerve-protecting properties.

What Does PEA Do In Our Body?

PEA, a fatty acid amide molecule, impacts several physiological processes related to inflammationand chronic pain. Neuroprotective, anti-inflammatory, anti-nociceptive (pain-relieving), and anti-convulsant effects have been shown.
When PEA production is low, it might exacerbate symptoms in patients with chronic illnesses. Clinical experiments have shown that taking PEA to make up for what the body lacks may help with inflammation and persistent neuropathic pain.
Some examples of peripheral neuropathies are those caused by chemotherapy, osteoarthritis, low back pain, failed back surgery syndrome, dental pains, neuropathic pain from stroke or M.S., chronic regional pain syndrome, chronic pelvic pain, postherpetic neuralgia, and vaginal pains. Diabetesand chemotherapy can also cause peripheral neuropathies.

Palmitoylethanolamide (PEA) For Migraines

Palmitoylethanolamide (PEA) has emerged as a potential game-changer in the realm of migraine management, offering a natural approach to alleviate pain and reduce the frequency of debilitating migraines.
As individuals seek effective alternatives to conventional treatments, the spotlight on "PEA for migraines" is growing brighter. Let's delve into the scientific evidence and explore how PEA may hold the key to not only reducing pain but also addressing the recurrent nature of migraines.

The Mechanism Of Pain Reduction With PEA

Scientific studies suggest that PEA operates through multiple mechanisms to reduce pain, making it a compelling candidate for migraine relief. PEA is known for its anti-inflammatory properties, modulating the immune response and curbing inflammatory pathways that are often implicated in migraine attacks.
By addressing the underlying inflammation, PEA may contribute to a significant reduction in the intensity of pain associated with migraines.
Moreover, PEA interacts with the endocannabinoid system, a complex network of receptors and compounds that play a crucial role in regulating various physiological processes, including pain perception.
Through its interaction with this system, PEA may influence the way the body processes and responds to pain signals, offering a potential avenue for not just masking pain symptoms but addressing them at their root.

Clinical Evidence

Clinical studies investigating the impact of PEA on migraines have yielded promising results. These studies indicate that PEA may not only reduce the intensity of pain but also contribute to a decrease in the frequency of migraine episodes.
A notable study conducted over a specific duration demonstrated a significant decline in the number of migraine attacks experienced by participants who incorporated PEA into their daily regimen. This evidence points towards the potential prophylactic effect of PEA in mitigating the recurrence of migraines.

Real-World Experiences

The experiences of individuals who have embraced PEA as part of their migraine management strategy provide valuable insights. Many have reported experiencing a noticeable reduction in the frequency of migraines after incorporating PEA into their daily routine.
While individual responses may vary, these real-world testimonials echo the findings from clinical studies, reinforcing the idea that PEA holds promise not just in addressing acute pain but also in offering sustained relief by minimizing the occurrence of migraines.

Dosage And Frequency

Determining the optimal dosage and frequency of PEA intake is a crucial aspect of its effectiveness in migraine management. Studies often recommend a specific dosage administered consistently over a defined period to observe substantial benefits.
While individual responses may dictate some variation in dosage, adhering to a regular schedule is critical in harnessing PEA's potential to reduce both pain and migraine frequency.

Addressing Recurrent Migraines

The recurrent nature of migraines poses a unique challenge for individuals seeking relief. PEA's potential to act as a preventive measure sets it apart from conventional treatments that often focus on symptom management.
By addressing the underlying factors that contribute to migraine recurrence, PEA offers a holistic approach that aligns with the growing trend toward personalized and preventive healthcare.

Challenges And Considerations In PEA Usage

While the evidence supporting PEA for migraines is promising, it's essential to acknowledge potential challenges and considerations. Individual responses to PEA may vary, and factors such as the severity of migraines, overall health, and existing medications can influence its efficacy.
Consulting with healthcare professionals to determine the optimal dosage and frequency tailored to individual needs is crucial to overcoming these challenges and maximizing the benefits of PEA for migraine relief.
Woman Feeling a Strong Head Pain
Woman Feeling a Strong Head Pain

What Are The Dangers Of Palmitoylethanolamide?

It is thought that the dietary supplement palmitoylethanolamide has analgesic and anti-inflammatory effects. There needs to be a more extensive study about the effectiveness and safety of this product. Feeling sick to your stomach, throwing up, having diarrhea, and abdominal discomfort are all potential adverse effects.
It would help if you talked to your doctor before taking this supplement since it may have negative interactions with other drugs you're already taking. Women who are pregnant or nursing, as well as individuals who have renal or hepatic illness, should not use it.

Palmitoylethanolamide (PEA) Regulation Worldwide

The regulatory status of palmitoylethanolamide (PEA) can vary across countries, and it's essential to note that regulations may have changed since then. PEA is often classified as a dietary supplement or nutraceutical rather than a pharmaceutical drug, which can influence its regulatory status.

United States

In the United States, PEA is generally regarded as a dietary supplement, and its regulatory status is overseen by the U.S. Food and Drug Administration (FDA). As a dietary supplement, PEA is subject to regulations outlined in the Dietary Supplement Health and Education Act (DSHEA).
It's important to note that dietary supplements are not intended to treat, cure, or prevent specific diseases, and manufacturers are responsible for ensuring the safety and labeling compliance of their products.

European Union

In the European Union, PEA is classified as a novel food, and its regulatory status falls under the European Food Safety Authority (EFSA). Novel foods are those that were not commonly consumed in the E.U. before May 1997. The approval process for novel foods involves a safety assessment by the EFSA before authorization for marketing within the E.U.


In Canada, PEA is available as a dietary supplement, and Health Canada manages its regulatory oversight. Similar to the U.S., dietary supplements in Canada are regulated under specific guidelines, and manufacturers are responsible for compliance with safety and labeling requirements.


In Australia, PEA may be available as a complementary medicine, and its regulation falls under the Therapeutic Goods Administration (TGA). Complementary medicines are assessed for safety, quality, and efficacy before being included in the Australian Register of Therapeutic Goods (ARTG).

Other Countries

Regulations regarding PEA in other countries may vary. Some countries may classify PEA as a dietary supplement, while others may have specific regulations governing its use. Individuals must check the specific regulations in their respective countries regarding the availability and use of PEA.
Tired Black Male Near Green Trees and Plants
Tired Black Male Near Green Trees and Plants


Regulatory Changes

Regulatory landscapes can change, and it's advisable to check for any updates or changes in regulations since my last knowledge update in January 2022.

Prescription Status

While PEA is often available as a supplement, there might be prescription formulations available in some countries, subject to different regulatory pathways.

Quality And Safety

Regardless of regulatory status, consumers should ensure they purchase PEA from reputable sources to guarantee quality and safety. Adherence to Good Manufacturing Practices (GMP) is an important aspect.

Consultation With Healthcare Professionals

Before using PEA for migraines or any other health condition, individuals should consult with healthcare professionals to ensure it is suitable for their specific situation and doesn't interact with any existing medications.

Frequently Asked Questions

Does PEA Help Migraines?

When it comes to neuroinflammation and inflammatory neuropathic pain, PEA is a proven anti-inflammatory that helps decrease nerve inflammation. The underlying cause of migraines is believed to be a kind of neuroinflammation.

Does PEA Reduce Pain?

With a standard mean difference of 1.68 (95% CI 1.05 to 2.31, p = 0.00001), PEA was found to lower pain ratings compared to comparators in a pooled estimate. Multiple research found that PEA improved participants' functional status and quality of life, and none of the studies linked PEA to serious adverse effects.

Is PEA Safe To Take?

When taken orally, PEA may not pose any health risks for periods of up to three months. Although it's generally well-tolerated, it can potentially make some individuals sick. We need more solid data to say if PEA is safe to take for more than three months. Applying PEA topically for up to 28 days may not cause any adverse effects.

How Fast Does PEA Work?

In the first six weeks, a greater dosage of 1,200 mg is often given in three separate doses. If the first dosage is effective, it may be gradually reduced to the lowest effective maintenance dose. You may not see any results for a couple of months.

Are There Any Reported Side Effects Or Considerations When Using PEA For Migraines?

While generally well-tolerated, individual responses to PEA may vary. It's essential to consider factors such as existing medical conditions and medications. Consulting with healthcare professionals helps tailor PEA usage for optimal safety and efficacy.

Can PEA Effectively Reduce The Frequency Of Migraines?

Emerging evidence suggests that PEA may contribute to a reduction in both the intensity and frequency of migraines. Studies indicate its potential as a prophylactic measure to minimize the recurrence of migraine episodes.

A Quick Recap

The exploration of Palmitoylethanolamide (PEA) as a natural remedy for migraines holds promise. Scientific evidence suggests that PEA's anti-inflammatory properties and interaction with the endocannabinoid system may contribute to migraine relief. As individuals navigate the complex landscape of migraine management, considering PEA as a complementary or alternative option warrants attention.
While more research is needed to solidify PEA's role in migraine treatment, the growing body of evidence and positive anecdotal experiences highlight its potential as a valuable addition to the toolkit for managing this debilitating condition.
As PEA for migraines continues to be a topic of interest and exploration, individuals are encouraged to consult with healthcare professionals to make informed decisions tailored to their unique health needs.
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